Cell Morphology

Cell morphology is essential in identifying the shape, structure, form, and size of cells. Kinetic morphology data provides key information on cell health and can be very useful in toxicity analyses, since morphology changes often precede cell damage and death.

Kinetic and Multi-parameter Assessment of Morphology

HoloMonitor® is designed to monitor changes in cell morphology over time. The analysis includes data for both individual cells and entire populations at the same time, allowing for non-invasive, fast and reliable analyses, in several research areas.

30+ Parameters tells the full story about your cells

HoloMonitor provides phase shift images that are information rich and enable detailed and kinetic analysis of more than 30 cell morphological parameters. All parameters are listed and defined in the HoloMonitor M4 Setup and Operational Manual.

Above: Some of the morphological parameters that can be analyzed using HoloMonitor. Below: The shape of cells changes continuously as cells move and divide. Using the HoloMonitor, these changes can be monitored and quantified.

HoloMonitor® Kinetic Morphology Assessment – A Multi-Parameter Toolbox

A vast line of morphological parameters can be determined over time using HoloMonitor. Changes in morphological parameters precede dramatic cellular events like mitosis and cell death, and can therefore be used as early and sensitive markers for detection of various drug effects and mode of actions. As all HoloMonitor applications morphology assessment is cell-friendly and analysed without the use of any labels or stains. Morphological parameters are, for example, useful

  • For evaluation of cell culture health and QC
  • As early and sensitive markers to detect  drug effects
  • To provide information on drug mode of action
  • For identification of dying cells

Morphology assessment can be used stand alone or in combination with other applications as cell proliferation, cell motility and migration, and cell cycle monitoring.