Translational Medicine in Pulmonary-Renal Crosstalk: Therapeutic Targeting of p-Cresyl Sulfate Triggered Nonspecific ROS and Chemoattractants in Dyspneic Patients with Uremic Lung Injury

J-F Chang et al

J. Clin. Med. (2018)

Institution: Fu Jen Catholic University, China

Cell Line: A549 (Human lung cancer cells)

Research Area: Uremic Lung Injury

Tags: HoloMonitor M4, p-cresyl sulfate, alveolar cell death, reactive oxygen species, cytokines, uremic lung injury, chronic kidney disease

Conclusions: Chronic kidney disease causes kidney failure, but there are also many side effects, e.g. respiratory distress called uremic lung injury. P-Cresyl sulfate (PCS) is produced when proteins ferment in intestinal bacteria, and accumulates in patients with chronic kidney disease. The authors found an effect of PCS on lung cancer cells as measured by cell count using HoloMonitor. The higher the concentration the more effect, until cell death was initiated. They tried to inhibit the effect of PCS with several different substances and used cell count here as well.

Read the article …