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WISP-1 Regulates Cardiac Fibrosis by Promoting Cardiac Fibroblasts’ Activation and Collagen Processing
Journal: Cells (2024)
Research Areas: Cardiac Function
Cell Lines: HFCs (human cardiac fibroblasts)
Summary: Hypertension induces cardiac fibrotic remodeling characterized by the phenotypic switching of cardiac fibroblasts (CFs) and collagen deposition. Collectively, the findings demonstrated WISP-1 is a critical mediator in cardiac fibrotic remodeling, by promoting CFs’ activation via the integrin β1-Akt signaling pathway, and induced collagen processing and maturation. A HoloMonitor timelapse was used for kinetic motility assessment, showing that WISP-1-induced activation increased CF motility.