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Cell migration can be defined as the movement of cells from one location to another in response to biological/chemical signals or environmental events. Impaired migration can contribute to pathological conditions in many disease areas like immune responses, tumor metastasis and angiogenesis.
Wound healing assays mimic in vivo cell migration. They are in vitro assays widely used in all kinds of research related to directed cell migration.
The HoloMonitor® Wound healing Assay is a classical wound healing, or scratch assay, optimized to easily provide kinetic, repetitive and semi-automatic result presentation of the gap closure and cell front velocity.
Gap closure decreases over time as the cells fill the gap. Untreated cells are used and the gap is created using the ibidi® Culture-Insert 2 Well.