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Doctoral Theses

Our [single-cell tracking] data clearly show that there are sub­populations of rapidly dividing cells, hiding in population-based data such as the population doubling time. Thus, by only drawing conclusions based on population data, important biological processes on individual cell levels may be neglected.

Dr. Sofia Kamlund, Lund University

  • Not all those who wander are lost: A study of cancer cells by digital holographic imaging, fluorescence and a combination thereof
    BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation, Lund University
    Sofia Kamlund (2019)

    In this thesis, cell division and cell movement of six different cell lines have been studied using digital holographic microscopy. A new way of analysing individual cells by using digital holographic microscopy alone, or in combination with fluorescence microscopy is presented.

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  • Characterization of the Novel Pericyte Receptors S1PR3 and PTGER2
    Faculty of Biosciences, Heidelberg University
    Tina Heumann (2017)
    Morphological changes were evaluated by comparing time-plots of cell volume and thickness, created by HoloMonitor M4.
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  • Proteins, Polymers and Living Cells on Titanium Oxide-based Nano structured Coatings: Exploitation of Label-free Optical Sensing Methods
    Institute of Technical Physics and Material Science, Center for Energy Research, Hungarian Academy of Sciences
    Judit Nádor (2016)

    The HoloMonitor M4 was used to monitor living cells (human embryonic kidney cells and preosteoblasts) on nanostructured coatings in a novel cuvette configuration.

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  • Aquaporins in Infection and Inflammation
    Clinical and Experimental Medicine, Linköping University
    Angelika Holm (2016)
    By recording time-lapse videos directly within the incubator using HoloMonitor M4, volume changes of bacteria infected cells was studied.
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  • Novel Imaging Technology and Tools for Biomarker Detection in Cancer
    Health and Society, Malmö University
    Zahra El-Schich (2016)
    To analyze morphological changes of death cells, HoloMonitor was used. Digital holographic microscopy is an approach for label-free non-invasive 3D imaging of cultured cells. We have analyzed cell death of adherent cancer cells using HoloMonitor and developed it to analyze suspension cells by combining this technique with antibody based micro­assays. HoloMonitor can be used for cell-death induced cell analysis of both adherent cells and suspension cells.
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  • Combination of Unsaturated Fatty Acids and Ionizing Radiation on Human Glioma Cells: Cellular, Biochemical and Gene Expression Analysis
    Department of Pharmaceutical Technology, University of Szeged
    Otilia Antal (2016)
    HoloMonitor M3 was used to assess the increased death of glioma (brain tumor) cells when combining irradiation with various unsaturated fatty acid treatments.
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  • Modulation of Tight Junctions by Peptides to Increase Drug Penetration Across Biological Barriers
    Department of Pharmaceutical Technology, University of Szeged
    Alexandra Bocsik (2016)
    Morphological changes in peptide treated Caco-2 epithelial cells were analyzed using HoloMonitor technology.
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  • Protection of the Blood-Brain Barrier under Pathological Conditions
    University of Szeged, Faculty of Medicine and Biological Research Centre Hungarian Academy of Sciences, Szeged
    Andrea Tóth (2014)

    Endothelial cells were cultured on collagen coated culture dishes with borosilicate glass bottom. HoloMonitor was used to analyze cell morphological changes before and during treatments.

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  • Nanowires in Cell Biology – Exploring Interactions and Applications
    Division of Solid State Physics, Lund University
    Henrik Persson (2014)
    Using HoloMonitor M4 this thesis explores the interactions between cells and nanowires, to increase our under­standing of how cells are affected and how they can be manipulated by these one-dimensional, semiconductor, crystals.
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  • Design of Reconfigurable Hardware Architectures for Real-Time Applications
    Department of Electrical and Information Technology, Lund University
    T. Lenart (2008)