Doctoral Theses
Our [single-cell tracking] data clearly show that there are subpopulations of rapidly dividing cells, hiding in population-based data such as the population doubling time. Thus, by only drawing conclusions based on population data, important biological processes on individual cell levels may be neglected.
Dr. Sofia Kamlund, Lund University
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Not all those who wander are lost: A study of cancer cells by digital holographic imaging, fluorescence and a combination thereofBioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation, Lund UniversitySofia Kamlund (2019)Read more
In this thesis, cell division and cell movement of six different cell lines have been studied using digital holographic microscopy. A new way of analysing individual cells by using digital holographic microscopy alone, or in combination with fluorescence microscopy is presented.
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Characterization of the Novel Pericyte Receptors S1PR3 and PTGER2Faculty of Biosciences, Heidelberg UniversityTina Heumann (2017)Read moreMorphological changes were evaluated by comparing time-plots of cell volume and thickness, created by HoloMonitor M4.
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Proteins, Polymers and Living Cells on Titanium Oxide-based Nano structured Coatings: Exploitation of Label-free Optical Sensing MethodsInstitute of Technical Physics and Material Science, Center for Energy Research, Hungarian Academy of SciencesJudit Nádor (2016)Read more
The HoloMonitor M4 was used to monitor living cells (human embryonic kidney cells and preosteoblasts) on nanostructured coatings in a novel cuvette configuration.
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Aquaporins in Infection and InflammationClinical and Experimental Medicine, Linköping UniversityAngelika Holm (2016)Read moreBy recording time-lapse videos directly within the incubator using HoloMonitor M4, volume changes of bacteria infected cells was studied.
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Novel Imaging Technology and Tools for Biomarker Detection in CancerHealth and Society, Malmö UniversityZahra El-Schich (2016)Read moreTo analyze morphological changes of death cells, HoloMonitor was used. Digital holographic microscopy is an approach for label-free non-invasive 3D imaging of cultured cells. We have analyzed cell death of adherent cancer cells using HoloMonitor and developed it to analyze suspension cells by combining this technique with antibody based microassays. HoloMonitor can be used for cell-death induced cell analysis of both adherent cells and suspension cells.
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Combination of Unsaturated Fatty Acids and Ionizing Radiation on Human Glioma Cells: Cellular, Biochemical and Gene Expression AnalysisDepartment of Pharmaceutical Technology, University of SzegedOtilia Antal (2016)Read moreHoloMonitor M3 was used to assess the increased death of glioma (brain tumor) cells when combining irradiation with various unsaturated fatty acid treatments.(in Hungarian)
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Modulation of Tight Junctions by Peptides to Increase Drug Penetration Across Biological BarriersDepartment of Pharmaceutical Technology, University of SzegedAlexandra Bocsik (2016)Read moreMorphological changes in peptide treated Caco-2 epithelial cells were analyzed using HoloMonitor technology.
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Protection of the Blood-Brain Barrier under Pathological ConditionsUniversity of Szeged, Faculty of Medicine and Biological Research Centre Hungarian Academy of Sciences, SzegedAndrea Tóth (2014)Read more
Endothelial cells were cultured on collagen coated culture dishes with borosilicate glass bottom. HoloMonitor was used to analyze cell morphological changes before and during treatments.
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Nanowires in Cell Biology – Exploring Interactions and ApplicationsDivision of Solid State Physics, Lund UniversityHenrik Persson (2014)Read moreUsing HoloMonitor M4 this thesis explores the interactions between cells and nanowires, to increase our understanding of how cells are affected and how they can be manipulated by these one-dimensional, semiconductor, crystals.
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Design of Reconfigurable Hardware Architectures for Real-Time ApplicationsDepartment of Electrical and Information Technology, Lund UniversityT. Lenart (2008)