August 30, 2017

Live Cell Imaging for Your Incubator

The real-time HoloMonitor live cell imaging system operates in your CO₂ cell incubator environment, hypoxia chamber or directly on the lab bench.

HoloMonitor is used by scientists all over the world to study the life cycle and behavior of living — or dying — cells, under physiologically optimal conditions. No stains needed. The non-invasive core technology, holographic microscopy, is cell-friendly, fast and simple to use, offering unique imaging capabilities for live cell kinetic investigations at single-cell and cell population level.

Developed by and for cell biologists, the HoloMonitor microscope system is designed to in vitro visualize and quantify adherent cells over time in an live cell incubator environment. The App Suite imaging and data analysis software allows researchers to create publication-ready images, videos and diagrams of cellular drug response and behavior, using a range of applications — all label-free.

Visualizes and Quantifies Cellular Events

HoloMonitor generates both visual elements and quantitative data. Visual elements, such as sequences of images and videos, illustrate cellular events taking place during the experiment, while quantitative data put numbers on what can be seen with the human eye.

From visual information in the holographic microscope images, the data is translated by sophisticated software algorithms into morphological parameters — optical cell volume, thickness, texture and many more — to provide kinetic cell analysis in your cell incubator.

Real-time Live Cell Imaging for Cell Incubators and Hypoxia Chambers

Cell-friendly

HoloMonitor and incubator-based live cell imaging allow cell cultures to be continuously monitored and analyzed over extended periods time under physiologically optimal conditions — in a standard CO₂ incubator or a hypoxia chamber. As all HoloMonitor applications are completely label-free, the risk of toxic effects masking drug-induced effects is reduced to a minimum.
Reliable and Cost-effective Operation

Since no labels or stains are needed, the assay protocols are straight forward and the experiments are quick and easy to set-up. A new and innovative mechanical design together with an intuitive software interface makes HoloMonitor operation simple and reliable.
Single-cell Studies on a Population Level

Images can be recorded with high temporal resolution, ensuring that important cellular events are not overlooked. This high temporal resolution is a key reason why HoloMonitor technology is optimal for kinetic studies to advance the understanding of processes such as cell growth, movements, division and cell death.
Long-term Live Cell Imaging Experiments in Your Incubator Environment

The incubator-compatible design makes the HoloMonitor system especially well suited for long-term kinetic cellular analyses. The low-intensity single-wavelength laser generates no heat, reducing the risk of photo-damage to an absolute minimum.