Customer Publication
Relevance of transportome among the mechanisms of chemoresistance in hepatoblastoma
Journal: Biochemical Pharmacology (2025)
Research Areas: Cancer Research
Cell Lines: HepG2, HuH6 cells (Human HB cell lines)
Summary: The main goal of the study was to investigate how the “transportome” contribute to chemoresistance in hepatoblastoma (HB). Specifically, they studied HB cells under both short-term (72 h) and long-term (>10 months) exposure to the chemotherapeutic agents Cisplatin and Doxorubicin, and monitored how the transportome changed (expression, function) and how that might underlie reduced drug sensitivity. They observed that HB cells adapted over long-term drug exposure by altering transporter-/channel-related gene expression (the “transportome”) in ways consistent with known resistance mechanisms. Based on their analysis, they proposed that certain transporters might serve as biomarkers for resistance in HB, and possibly as therapeutic targets to overcome chemoresistance. HoloMonitor M4 was used to study the cell proliferation of the HB cells