Doctoral Theses


Our [single-cell tracking] data clearly show that there are sub­populations of rapidly dividing cells, hiding in population-based data such as the population doubling time. Thus, by only drawing conclusions based on population data, important biological processes on individual cell levels may be neglected.

Dr. Sofia Kamlund, Lund University

  • Modulation of Tight Junctions by Peptides to Increase Drug Penetration Across Biological Barriers
    Department of Pharmaceutical Technology, University of Szeged
    Alexandra Bocsik (2016)
    Morphological changes in peptide treated Caco-2 epithelial cells were analyzed using HoloMonitor technology.
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  • Combination of Unsaturated Fatty Acids and Ionizing Radiation on Human Glioma Cells: Cellular, Biochemical and Gene Expression Analysis
    Department of Pharmaceutical Technology, University of Szeged
    Otilia Antal (2016)
    HoloMonitor M3 was used to assess the increased death of glioma (brain tumor) cells when combining irradiation with various unsaturated fatty acid treatments.
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  • Novel Imaging Technology and Tools for Biomarker Detection in Cancer
    Health and Society, Malmö University
    Zahra El-Schich (2016)
    To analyze morphological changes of death cells, HoloMonitor was used. Digital holographic microscopy is an approach for label-free non-invasive 3D imaging of cultured cells. We have analyzed cell death of adherent cancer cells using HoloMonitor and developed it to analyze suspension cells by combining this technique with antibody based micro­assays. HoloMonitor can be used for cell-death induced cell analysis of both adherent cells and suspension cells.
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  • Living cells and copolymer coatings exposed to green tea polyphenol (EGCg): dynamic investigations using label-free optical biosensors
    University of Pannonia, Hungary
    Beatrix Eva Peter (2016)

    HoloMonitor M4 was used to study cell movements and cell mormorphology changes during green tea polyphenol (EGCg) liposome treatments.

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  • Combination Liposome-Based Anti-Cancer Preparations
    Northeastern University, Boston Massachusetts
    Shravan Kumar Sriraman (2015)

    HoloMonitor M4 was used to study cell movements and cell morphology changes after liposome treatments.

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  • Nanowires in Cell Biology – Exploring Interactions and Applications
    Division of Solid State Physics, Lund University
    Henrik Persson (2014)
    Using HoloMonitor M4 this thesis explores the interactions between cells and nanowires, to increase our under­standing of how cells are affected and how they can be manipulated by these one-dimensional, semiconductor, crystals.
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  • Protection of the Blood-Brain Barrier under Pathological Conditions
    University of Szeged, Faculty of Medicine and Biological Research Centre Hungarian Academy of Sciences, Szeged
    Andrea Tóth (2014)

    Endothelial cells were cultured on collagen coated culture dishes with borosilicate glass bottom. HoloMonitor was used to analyze cell morphological changes before and during treatments.

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  • Design of Reconfigurable Hardware Architectures for Real-Time Applications
    Department of Electrical and Information Technology, Lund University
    Thomas Lenart (2008)