Journal: Translational Oncology (2023)
Institution: University of Bristol Southmead Hospital
Research Areas: Cancer Research
Cell Lines: LNCaP, 22Rv1, VCaP (mycoplasma)
Summary: Prostate cancer (PCa) is one of the leading causes of cancer-related deaths in men. Localised PCa can be treated effectively, but most patients relapse/progress to more aggressive disease. One possible mechanism underlying this progression is alternative splicing of the androgen receptor, with AR variant 7(ARV7) considered to play a major role. In this paper, authors confirmed that ARV7-positive PCa cells were less sensitive to anti-cancer treatments. Also, with HoloMonitor ,they showed PCa cells with ARV7 exhibited an increased rate of cell division, proliferation, and motility, which could potentially contribute to a more aggressive phenotype. Furthermore, data suggest an interplay of FOXA1 and IGFBP-2 with ARV7-mediated acquisition of an aggressive prostate cancer phenotype.HoloMonitor M4 was used to study the proliferation, cell motility and cell division.