A Unifying Mechanism for Cancer Cell Death Through Ion Channel Activation by Hamlet

P. Storm et al.

PLOS One (2013)

Institution: Lund University, Sweden

Cell Line: A549, HeLa, A498 (A549-lung carcinoma cells, HeLa-cervical carcinoma cells, A498-kidney carcinoma cells)

Research Area: Action of HAMLET

Tags: HoloMonitor M2, Cell morphology, Carcinoma, Cell death , Ion channels, MAPK signaling cascades, Cell differentiation, Lung and intrathoracic tumors, Cell membranes, Apoptosis

Conclusions: Ion channels and ion fluxes control many aspects of tissue homeostasis. During oncogenic transformation, critical ion channel functions may be perturbed but conserved tumor-specific ion fluxes remain to be defined. Here authors used the tumoricidal protein-lipid complex HAMLET as a probe to identify ion fluxes involved in tumor cell death. Results suggest that HAMLET offers a two-tiered therapeutic approach, killing cancer cells while stimulating an innate immune response in surrounding healthy tissues. Changes in cell morphology were studied using HoloMonitor technology

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