Customer Publication

A Unifying Mechanism for Cancer Cell Death Through Ion Channel Activation by Hamlet

Authors: Petter Storm, Thomas Kjaer Klausen, Maria Trulsson, James Ho CS, Marion Dosnon, Tomas Westergren, Yinxia Chao, Anna Rydström, Henry Yang, Stine Falsig Pedersen, Catharina Svanborg

Journal: PLOS One (2013)

Institution: Lund University

Research Areas: Cancer research

Cell Lines: A549, HeLa, A498 (A549-lung carcinoma cells, HeLa-cervical carcinoma cells, A498-kidney carcinoma cells)

Summary: Ion channels and ion fluxes control many aspects of tissue homeostasis. During oncogenic transformation, critical ion channel functions may be perturbed but conserved tumor-specific ion fluxes remain to be defined. Here authors used the tumoricidal protein-lipid complex HAMLET as a probe to identify ion fluxes involved in tumor cell death. Results suggest that HAMLET offers a two-tiered therapeutic approach, killing cancer cells while stimulating an innate immune response in surrounding healthy tissues. Changes in cell morphology were studied using HoloMonitor technology

Keywords: HoloMonitor M2, Cell morphology, Carcinoma, Cell death, Ion channels, MAPK signaling cascades, Cell differentiation, Lung and intrathoracic tumors, Cell membranes, Apoptosis, Action of HAMLET

Read the article …