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Accumulation of Simulated Pathological Level of Formaldehyde Decreases Cell Viability and Adhesive Morphology in Neuronal Cells

Authors: Wang Jing, Zhou Jun, Mo Wei-Chuan, He Ying-Ge, Wei Yan, He Rong-Qiao, Yi Fa-Ping

Journal: Progress in Biochemistry and Biophysics (2017)

Institution: Chongqing Medical University

Research Areas: Neuroscience

Cell Lines: N-2a cells (Murine neuroblastoma neuro)

Summary: Age-related cognitive impairment, for instance, Alzheimer's disease (AD), is a chronic, progressive neurodegeneration disease. The concentration of endogenous formaldehyde (FA) positively correlates with the severity of cognitive impairments in AD patients. Chronic formaldehyde (FA) exposure leads to impairment of human memory. In this study, the authors established a cell culture method to simulate the chronic low-concentration FA exposure by using a serial passage strategy. HoloMonitor M3 was used to illustrate how FA exposure influences cell morphology regarding thickness, area, and volume.

Keywords: HoloMonitor M3, Formaldehyde, Cell viability, Neural connectivity, tau hyper phosphorylation, Cell morphology, Aging

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