Customer Publication

Accumulation of Simulated Pathological Level of Formaldehyde Decreases Cell Viability and Adhesive Morphology in Neuronal Cells

Authors: W. Jing et al.

Journal: Progress in Biochemistry and Biophysics (2017)

Institution: Chongqing Medical University

Research Areas: Aging

Cell Lines: N-2a cells (Murine neuroblastoma neuro)

Summary: Age-related cognitive impairment, for instance, Alzheimer's disease (AD), is a chronic, progressive neurodegeneration disease. The concentration of endogenous formaldehyde (FA) positively correlates with the severity of cognitive impairments in AD patients. Chronic formaldehyde (FA) exposure leads to impairment of human memory. In this study, the authors established a cell culture method to simulate the chronic low-concentration FA exposure by using a serial passage strategy. HoloMonitor M3 was used to illustrate how FA exposure influences cell morphology regarding thickness, area, and volume.

Keywords: HoloMonitor M3, Formaldehyde, Cell viability, Neural connectivity, tau hyper phosphorylation, Cell morphology

Read the article …

Phase Holographic Imaging PHI AB
Skiffervägen 48
224 78 Lund
Sweden
+46 46 38 60 80
info@phiab.se

Phase Holographic Imaging PHI Inc.
265 Franklin Street Suite 1702
Boston, MA 02110
USA
+1 617-963-5150
info@phiab.com

Invoicing

VAT: SE556542781101
faktura@phiab.se

Securities Identification

ISIN: SE0005504636
LEI: 549300JZR79QYESM6296

HoloMonitor® is a registered trademark
Copyright © 2012-2021
Phase Holographic Imaging PHI AB

Phase Holographic Image logo in white

PHI Theme 3.12.2