Actin polymerization and cell motility are affected by NAA80-mediated posttranslational N-terminal acetylation of actin
Journal: Communicative & Integrative Biology (2018)
Institution: University of Bergen
Research Areas: Cell Research
Cell Lines: HAP1 (Near-haploid human cell)
Summary: It is well known that actin plays an essential role in muscle cell contraction, and cellular functions like skeleton/structure-function, organelle trafficking and cell migration. The authors studied how NAA80, by acetylating actin’s N-terminus, acts as a natural brake in the cells. Single-cell identification and tracking of movement was performed with HoloMonitor, and single-cell analysis used to demonstrate the power of this mechanism.