Customer Publication

Alkyl-carbon chain length of two distinct compounds and derivatives are key determinants of their anti-Acanthamoeba activities

Authors: Ronnie Mooney, Mariana Masala, Theo Martial, Charles McGinness, Fiona Luisa Henriquez, Roderick Adeyinka Malcolm Williams

Journal: Scientific Reports (2020)

Institution: University of the West of Scotland

Research Areas: Cytotoxicity

Cell Lines: Acanthamoeba castellanii (Amobea)

Summary: Acanthamoeba are free-living protists, who have opportunistic tendencies. Thus, they can affect the skin, cause severe cornea infections, or in rare cases lead to death. If Acanthamoeba damage the cornea, it can lead to sight loss. Consequently, in this publication, R. Moorey with colleagues, have studied how two molecules affect A. castellani trophozoites and showed that these molecules can be useful for preventing amoeba cornea infections, i.e. by formulating them into contact lens solution. In this study, authors have used HoloMonitor M4 to characterize how the treatment affects A. castellanii morphology: area, perimeter, and volume.

Keywords: HoloMonitor M4, Cell morphology, quaternary ammonium compounds, Parasitic infections

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