Applications of Label-free, Quantitative Phase Holographic Imaging Cytometry to the Development of Multi-specific Nanoscale Pharmaceutical Formulations

Authors: E. Luther et al.

Journal: Cytometry Part A 2017 (2017)

Institution: Northeastern University

Cell Lines: HeLa, L929 (HeLa:Human cervical cancer; L929: mouse fibroblast)

Summary: A review of HoloMonitor applications: tracking of Giant HeLa cells, which may be undergoing neosis tracking the effects of cell cycle-related toxic agents on cell lines; using MicroRNAs to reverse the polarization state in macrophages to induce tumor cell killing the development of liposomal nanoformulations to overcome multidrug resistance in ovarian cancer cells and development of dual sensitive micelles to specifically target matrix metalloproteinase,

Keywords: Review, HoloMonitor M4, Holographic imaging, Label-free, Time-lapse, 4-D imaging

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