Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation

H. Zeng et al.

Cancer Cell (2018)

Country: USA

Cell Line: Melanocytes (Engineered primary human melanocytes)

Research Area: Melanoma

Tags: HoloMonitor M4, Cell division, Cell death, Senescence, Cell motility , CDKN2A, Melanoma, Invasion, Melanocytes, CRISPR engineering, E2F1 BRN2

Conclusions: Utilizing precision genetic engineering and PHI’s HoloMonitor technology, scientists at University of California, San Francisco, have for the first time been able to monitor and map how mutations break down the genetic protection against skin cancer, allowing harmless moles to transform into invasive skin cancer.

Read the article …