Customer Publication

Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation

Authors: Hanlin Zeng, Aparna Jorapur, A. Hunter Shain, Ursula E. Lang, Rodrigo Torres, Yuntian Zhang, Andrew S. McNeal, Thomas Botton, Jue Lin, Matthew Donne, Ingmar N. Bastian, Richard Yu, Jeffrey P. North, Laura Pincus, Beth S. Ruben, Nancy M. Joseph, Iwei Yeh, Boris C. Bastian, Robert L. Judson

Journal: Cancer Cell (2018)

Institution: Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA

Research Areas: Cancer research

Cell Lines: Melanocytes (Engineered primary human melanocytes)

Summary: Utilizing precision genetic engineering and PHI’s HoloMonitor technology, scientists at University of California, San Francisco, have for the first time been able to monitor and map how mutations break down the genetic protection against skin cancer, allowing harmless moles to transform into invasive skin cancer.

Keywords: HoloMonitor M4, Cell division, Cell death, Senescence, Cell motility, CDKN2A, Melanoma, Invasion, Melanocytes, CRISPR engineering, E2F1 BRN2

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