Biophysical characterization of nanostructured TiO2 as a good substrate for hBM-MSC adhesion, growth and differentiation
Journal: Experimental Cell Research (2017)
Institution: Institute of Biophysics, National Research Council, Genova
Research Areas: Materials of Science
Cell Lines: hBM-MSC (Mesenchymal stem cells from human bone marrow)
Summary: Evaluation of the effectiveness of a nano-patterned titanium surface in sustaining hBM-MSC adhesion, growth and differentiation by means of a panel of biophysical tools: morphometry, electrophysiology, intracellular calcium measurements and immunocytochemistry. The results substantiate the idea that this micro-textured titanium dioxide is a good surface for growth and differentiation of hBM-MSC and it exhibits a stimulating action mainly in the initial period of differentiation. HoloMonitor was used for analysis of various morphological parameters.