Ca2+ signals, cell membrane disintegration, and activation of tmem16f during necroptosis
Journal: Cellular and molecular life sciences (2016)
Institution: Universität Regensburg
Research Areas: Cell death
Cell Lines: NIH3T3, HT29 (Mouse embryonic fibroblasts and human colonic carcinoma)
Summary: It is well known that cells swell during necroptosis. However, proper cell volume measurements are still missing. Using HoloMonitor M4 the authors non-invasively measured the cell volume changes associated with necroptosis. The results were confirmed by flow cytometry measurements.