Ca2+ signals, cell membrane disintegration, and activation of tmem16f during necroptosis

J. Ousingsawat et al.

Cellular and molecular life sciences (2016)

Institution: Universität Regensburg, Germany

Cell Line: NIH3T3, HT29 (Mouse embryonic fibroblasts and human colonic carcinoma)

Research Area: Cell death

Tags: HoloMonitor M4, cell death, Ca2+ signaling,

Conclusions: It is well known that cells swell during necroptosis. However, proper cell volume measurements are still missing. Using Holo­Monitor M4 the authors non-invasively measured the cell volume changes associated with necroptosis. The results were confirmed by flow cytometry measurements.

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