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CAT3, a prodrug of 13a(S)-3-hydroxyl-6,7-dimethoxyphenanthro[9,10-b]-indolizidine, circumvents temozolomide-resistant glioblastoma via the Hedgehog signaling pathway, independently of O6-methylguanine DNA methyltransferase expression
Journal: OncoTargets and Therapy (2018)
Institution: Chinese Academy of Medical Sciences and Peking Union Medical College
Research Areas: Cancer research
Cell Lines: U251/TMZ and T98G (TMZ-resistant glioblastoma cell lines)
Summary: The results indicate that CAT3 is a potential therapeutic agent for TMZ-resistant GBM (glioblastoma multiforme). HoloMonitor M4 was used to directly monitor and calculate the cell number.