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CAT3, a prodrug of 13a(S)-3-hydroxyl-6,7-dimethoxyphenanthro[9,10-b]-indolizidine, circumvents temozolomide-resistant glioblastoma via the Hedgehog signaling pathway, independently of O6-methylguanine DNA methyltransferase expression

Authors: Ji M , Wang L, Chen J, Xue N, Wang C , Lai F, Wang R, Yu SS, Jin J, Chen X

Journal: OncoTargets and Therapy (2018)

Institution: Chinese Academy of Medical Sciences and Peking Union Medical College

Research Areas: Cancer research

Cell Lines: U251/TMZ and T98G (TMZ-resistant glioblastoma cell lines)

Summary: The results indicate that CAT3 is a potential therapeutic agent for TMZ-resistant GBM (glioblastoma multiforme). HoloMonitor M4 was used to directly monitor and calculate the cell number.

Keywords: HoloMonitor M4, Cell count, Gli inhibitor, Chemotherapy, Lomeguatrib, Xenograft tumor model

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