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Cathelicidins Positively Regulate Pancreatic Β-cell Functions
Journal: The FASEB Journal (2016)
Institution: Jiangnan University
Research Areas: Immunology
Cell Lines: INS-1, INS-1 832/13 (INS-1 832/13, a modified rat insulinoma INS-1 cell clone stably transfected with the human proinsulin gene,)
Summary: Cathelicidins are largely described for innate antimicrobial defenses and immunomodulation. They are shown to modulate a variety of immune or nonimmune host cell responses. However, how cathelicidins are expressed by β cells and modulate β-cell functions are unknown. Their finding suggests that cathelicidins positively regulate β-cell functions and may be potentially used for intervening β-cell dysfunction-associated diseases. HoloMonitor M4 was used to assess the cell density during cell proliferation.