Customer Publication

Cathelicidins Positively Regulate Pancreatic Β-cell Functions

Authors: Jia Sun, Meng Xu, Henrik Ortsäter, Erik Lundeberg, Lisa Juntti-Berggren, Yong Q. Chen, Jesper Z. Haeggström, Gudmundur H. Gudmundsson, Julien Diana, Birgitta Agerberth

Journal: The FASEB Journal (2016)

Institution: Jiangnan University

Research Areas: Immunology

Cell Lines: INS-1, INS-1 832/13 (INS-1 832/13, a modified rat insulinoma INS-1 cell clone stably transfected with the human proinsulin gene,)

Summary: Cathelicidins are largely described for innate antimicrobial defenses and immunomodulation. They are shown to modulate a variety of immune or nonimmune host cell responses. However, how cathelicidins are expressed by β cells and modulate β-cell functions are unknown. Their finding suggests that cathelicidins positively regulate β-cell functions and may be potentially used for intervening β-cell dysfunction-associated diseases. HoloMonitor M4 was used to assess the cell density during cell proliferation.

Keywords: HoloMonitor M4, Cell morphology, Antimicrobial, Peptdide, CRAMP, Immunomodulation, Endocrine cells, Type 1 diabetes, Immunregulation

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