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CFTR supports cell death through ROS-dependent activation of TMEM16F (anoctamin 6)

Authors: Filipa Simões, Jiraporn Ousingsawat, Podchanart Wanitchakool, Ana Fonseca, Inês Cabrita, Roberta Benedetto, Rainer Schreiber, Karl Kunzelmann

Journal: Eur J Physiol (2017)

Institution: Universität Regensburg

Research Areas: Cell research

Cell Lines: HEK293, HeLa, and CFBE cells (Human embryonic kidney cells (HEK293), human cervical cancer ( HeLa), and cystic fibrosis bronchial epithelial (CFBE) cells)

Summary: Mechanism in cystic fibrosis; role of induced cell death by reactive oxygen species (ROS) was investigated. Cell volume measurements using HoloMonitor was used to assess cell shrinkage during cell death.

Keywords: HoloMonitor, Cell morphology, CFTR, Cystic fibrosis

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