Customer Publication

Characterization of macrophage behavior by 4-dimensional label free quantitative holographic imaging

Authors: E. Luther et al.

Journal: AACR Annual Meeting (2015)

Institution: Northeastern university

Summary: The tumor microenvironment consists of several cell types including cancer cells and stromal cells (fibroblasts and inflammatory cells) embedded in the extracellular matrix. Among the inflammatory cells, macrophages are critical mediators of tumorigenesis. Their behavior and activation is controlled by a large number of chemo-stimulants, and are broadly classified into two polarization groups, M1 (classically activated macrophages), that enable the release of cytokines and chemokines that induce tumor suppression and M2 (alternatively activated macrophages), that induce tissue repair and angiogenesis. In the tumor microenvironment, this translates into tumor promotion. We employed a newly developed label-free holographic time-lapse imaging system to characterize the morphology and motility of macrophages in response to stimulants and tumor cells in 4- dimensional models of the tumor microenvironment.

Keywords: Poster, tumor microenvironment, macrophage, digital holography

Read the article …

Phase Holographic Imaging PHI AB
Skiffervägen 48
224 78 Lund
+46 46 38 60 80

Phase Holographic Imaging PHI Inc.
265 Franklin Street Suite 1702
Boston, MA 02110
+1 617-963-5150


VAT: SE556542781101

Securities Identification

ISIN: SE0005504636
LEI: 549300JZR79QYESM6296

HoloMonitor® is a registered trademark
Copyright © 2012-2021
Phase Holographic Imaging PHI AB

Phase Holographic Image logo in white

PHI Theme 3.12.2