Characterization of a green, temperature activated nano formulation that drives the mechanism of doxorubicin toxicity from apoptosis to ferroptosis
Journal: AACR Annual Meeting (2022)
Institution: Northeastern University, Boston, MA
Research Areas: Cancer research, Biotechnology
Cell Lines: B16F10, U87-MR, MDA-MB-231, MCF-7
Summary: The authors have developed a green, temperature-activated nano formulation (TAN) to deliver doxorubicin to cancer cells. To evaluate the temporal effects of the formulation, they use HoloMonitor® M4 for 4-dimensional imaging (X pos vs. Y pos vs. Time vs. Density). Their conclusion is that the newly developed TAN is highly potent and likely kills cancer cells by inducing ferroptosis.HoloMonitor M4 was used for proliferation and cell tracking assays.