Characterization of a Transgenic Mouse Model Exhibiting Spontaneous Lung Adenocarcinomas With a Metastatic Phenotype

H. Chang et al.

PLOS ONE (2017)

Institution: Taipei Medical University, Taiwan

Cell Line: Tg-3m and Tg-6m (Primary mouse lung adenocarcinoma)

Research Area: Cancer research

Tags: HoloMonitor M4, Cell motility, Cell morphology, Non-small cell lung cancer , Adenocarcinoma, Adenocarcinoma of the lung, Thyroid carcinoma, Nasopharyngeal carcinoma

Conclusions: The authors have developed a mouse model which is very similar to human, and which can be used for more relevant drug evaluations. Focus are is tumor metatasis and especially the phenomenon of the epithelial-mesenchymal transition (EMT). HoloMonitor was used to investigate the capability of cell movement of tumor cells at different stages.

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