Characterization of a Transgenic Mouse Model Exhibiting Spontaneous Lung Adenocarcinomas With a Metastatic Phenotype
PLOS ONE (2017)
Institution: Taipei Medical University, Taiwan
Cell Line: Tg-3m and Tg-6m (Primary mouse lung adenocarcinoma)
Research Area: Cancer research
Conclusions: The authors have developed a mouse model which is very similar to human, and which can be used for more relevant drug evaluations. Focus are is tumor metatasis and especially the phenomenon of the epithelial-mesenchymal transition (EMT). HoloMonitor was used to investigate the capability of cell movement of tumor cells at different stages.