Customer Publication

Colony Formation, Migratory, and Differentiation Characteristics of Multipotential Stromal Cells (MSCs) from “Clinically Accessible” Human Periosteum Compared to Donor-Matched Bone Marrow MSCs

Authors: H. Owston et al.

Journal: Stem Cells International (2019)

Institution: University of Leeds

Research Areas: Stem cell therapy

Cell Lines: Primary BM and primary MSC (Primary BM - primary human bone marrow cells Primary MSC - primary human multipotential stromal cells)

Summary: Periosteum, a highly vascular and multipotential stromal cell- (MSC-) rich tissue, is vital for fracture healing. In this study, H. E. Owston et al aimed to compare human periosteum and donor-matched iliac crest BM MSC content. They also characterized MSCs in terms of colony formation, growth kinetics, phenotype, cell migration patterns, and trilineage differentiation capacity. Authors have used HoloMonitor M4 to show that in early culture, periosteum cells were less migratory at slower speeds than BM cells. Live cell tracking allowed to determine unique morphological and migration characteristics of periosteal MSCs that can be used to develop novel bone graft substitutes.

Keywords: HoloMonitor M4, cell morphology and cell movements, multipotential stromal cell

Read the article …

Phase Holographic Imaging PHI AB
Skiffervägen 48
224 78 Lund
+46 46 38 60 80

Phase Holographic Imaging PHI Inc.
265 Franklin Street Suite 1702
Boston, MA 02110
+1 617-963-5150


VAT: SE556542781101

Securities Identification

ISIN: SE0005504636
LEI: 549300JZR79QYESM6296

HoloMonitor® is a registered trademark
Copyright © 2012-2021
Phase Holographic Imaging PHI AB

Phase Holographic Image logo in white

PHI Theme 3.12.2