Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi
Journal: Nature Communications (2017)
Institution: University of California, San Francisco
Research Areas: Melanoma
Cell Lines: Melana-a (Stably tranduced melanocytes)
Summary: HoloMonitor was used to measure cell volume. Together with other methods the results identify DPN (deep penetrating nevus) as an intermediate melanocytic neoplasm, with a progression stage positioned between benign nevus and DPN-like melanoma.