Customer Publication

Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi

Authors: Iwei Yeh, Ursula E. Lang, Emeline Durieux, Meng Kian Tee, Aparna Jorapur, A. Hunter Shain, Veronique Haddad, Daniel Pissaloux, Xu Chen, Lorenzo Cerroni, Robert L. Judson, Philip E. LeBoit, Timothy H. McCalmont, Boris C. Bastian, Arnaud de la Fouchardière

Journal: Nature Communications (2017)

Institution: University of California, San Francisco

Research Areas: Cancer research

Cell Lines: Melana-a (Stably tranduced melanocytes)

Summary: HoloMonitor was used to measure cell volume. Together with other methods the results identify DPN (deep penetrating nevus) as an intermediate melanocytic neoplasm, with a progression stage positioned between benign nevus and DPN-like melanoma.

Keywords: HoloMonitor M4, Cell morphology, Deep penetrating nevus, Melanoma

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