Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi

Authors: I. Yeh et al.

Journal: Nature Communications (2017)

Institution: University of California, San Francisco

Research Areas: Melanoma

Cell Lines: Melana-a (Stably tranduced melanocytes)

Summary: HoloMonitor was used to measure cell volume. Together with other methods the results identify DPN (deep penetrating nevus) as an intermediate melanocytic neoplasm, with a progression stage positioned between benign nevus and DPN-like melanoma.

Keywords: HoloMonitor M4, Cell morphology, Deep penetrating nevus

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