Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi

I. Yeh et al.

Nature Communications (2017)

Institution: University of California, USA

Cell Line: Melana-a (Stably tranduced melanocytes)

Research Area: Melanoma

Tags: HoloMonitor M4, Cell morphology, Deep penetrating nevus

Conclusions: HoloMonitor was used to measure cell volume. Together with other methods the results identify DPN (deep penetrating nevus) as an intermediate melanocytic neoplasm, with a progression stage positioned between benign nevus and DPN-like melanoma.

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