Cystatin C Decreases Proliferation of Melanoma Cells by Affecting Mitosis Length

Authors: Hanna Wallin et al.

Journal: AACR Annual Meeting (2017)

Institution: Lund University

Summary: Analysis using HoloMonitor revealed qualitative differences in the normal behavior of the A375 cells under study as a result of cystatin C addition. The motility of the cells was significantly affected. The mitosis phase was considerably prolonged in cells grown in cystatin C containing medium, indicating that the proliferation-inhibiting effect of the protease inhibitor may be through its direct action on proteolytic processes in the mitosis phase.

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