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Defining COMMD4 as an anti-cancer therapeutic target and prognostic factor in non-small cell lung cancer

Authors: Amila Suraweera, Alex Duff, Mark N. Adams, Christian Jekimovs, Pascal H. G. Duijf, Cheng Liu, Matthew McTaggart, Sam Beard, Kenneth J. O’Byrne, Derek J. Richard

Journal: British Journal of Cancer (2020)

Institution: Queensland University of Technology

Research Areas: Cancer research

Cell Lines: HBEC3-KT, H460, H1975, CRL5889 (HBEC3-KT, H460, H1975, CRL5889)

Summary: Despite current advances in cancer therapy, novel therapeutic targets and cancer therapies are needed to improve non-small lung patient prognosis and treatment. In this study, A. Suraweera with colleagues has identified that COMMD4 protein, which controls DNA transcription protein, can also function as a prognostic factor in non-small lung cancer and can be a therapeutic target. Authors have used HoloMonitor M4 to study cell proliferation changes after COMMD4 gene depletion.

Keywords: HoloMonitor M4, Cell proliferation, Non-small cell lung cancers, COMMD4

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