Customer Publication

Dermatan Sulfate Is Involved in the Tumorigenic Properties of Esophagus Squamos Cell Carcinom

Authors: Martin A. Thelin, Katrin J. Svensson, Xiaofeng Shi, Mariam Bagher, Jakob Axelsson,Anna Isinger-Ekstrand, Toin H. van Kuppevelt, Jan Johansson, Mef Nilbert, Joseph Zaia, Mattias Belting, Marco Maccarana, Anders Malmström

Journal: Cancer Research (2012)

Institution: Lund university

Research Areas: Cancer research

Cell Lines: TE1 (Human squamous cell carcinoma of the esophagus)

Summary: Chondroitin and dermatan sulfate proteoglycans, which occur both in the matrix and at the cell surface, play important roles in thetumorgenic processes. The unique feature that distinguishes DS from CS is the presence of iduronic acid (IdoA) in DS. IdoA in DS influences tumorigenesis by affecting cancer cell behavior

Keywords: HoloMonitor, Cell morphology

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