Customer Publication

Dual role of exosomal circCMTM3 derived from GSCs in impeding degradation and promoting phosphorylation of STAT5A to facilitate vasculogenic mimicry formation in glioblastoma

Authors: Chengbin Wang et al.

Journal: Theranostics (2024)

Research Areas: Cancer Research

Cell Lines: GSC01, GSC03 (patient-derived glioblastoma stem cells)

Summary: This paper explores the role of circular RNA (circRNA) in glioblastoma neovascularization. The researchers identified a circRNA, circCMTM3, in exosomes derived from glioblastoma cells, which, when internalized by differentiated glioblastoma cells (DGCs), induces a vascular-like phenotype. circCMTM3 prevents the degradation and promotes the activation of STAT5A, a protein that subsequently increases the expression of genes promoting blood vessel formation. The authors used the single-cell tracking capabilities of HoloMonitor M4 to visualize the migration of DGCs treated with glioblastoma-derived exosomes. They suggest circCMTM3 as a potential target for anti-vasculogenic therapies for glioblastoma.

Keywords: glioblastoma stem cells, exosome, circrna, vasculogenic mimicry, cnot4, stat5a

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