Edaravone Protects Against Methylglyoxal-induced Barrier Damage in Human Brain Endothelial Cells
PLOS ONE (2014)
Institution: Hungarian Academy of Sciences, Hungary
Cell Line: hCMEC/D3 (Human brain endothelial cells)
Research Area: Drug development
Conclusions: Using holographic microscopy for label-free analysis of living cells, visualized for the first time the kinetics of morphological changes caused by methylglyoxal. The morphology data confirmed that edavarone completely prevented methylglyoxal-induced changes in morphology and detachment of cells.