Customer Publication

Edaravone Protects Against Methylglyoxal-induced Barrier Damage in Human Brain Endothelial Cells

Authors: Andrea E. Tóth, Fruzsina R. Walter, Alexandra Bocsik, Petra Sántha, Szilvia Veszelka, Lajos Nagy, László G. Puskás, Pierre-Olivier Couraud, Fuyuko Takata, Shinya Dohgu, Yasufumi Kataoka, Mária A. Deli

Journal: PLOS ONE (2014)

Institution: Hungarian Academy of Sciences

Research Areas: Drug research

Cell Lines: hCMEC/D3 (Human brain endothelial cells)

Summary: Using holographic microscopy for label-free analysis of living cells, visualized for the first time the kinetics of morphological changes caused by methylglyoxal. The morphology data confirmed that edavarone completely prevented methylglyoxal-induced changes in morphology and detachment of cells.

Keywords: Holomonitor M3, cell morphology, mode of action, drug against brain damage after acute brain ischemia and infarction, Drug development

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