Edaravone Protects Against Methylglyoxal-induced Barrier Damage in Human Brain Endothelial Cells

Authors: A. Tóth et al.

Journal: PLOS ONE (2014)

Institution: Hungarian Academy of Sciences

Research Areas: Drug development

Cell Lines: hCMEC/D3 (Human brain endothelial cells)

Summary: Using holographic microscopy for label-free analysis of living cells, visualized for the first time the kinetics of morphological changes caused by methylglyoxal. The morphology data confirmed that edavarone completely prevented methylglyoxal-induced changes in morphology and detachment of cells.

Keywords: Holomonitor M3, cell morphology, mode of action. drug against brain damage after acute brain ischemia and infarction

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