Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis
Journal of Translational Medicine (2019)
Institution: Henan University, China
Cell Line: HL-60 and LLC (HL-60 - human acute promyelocytic leukemia; LLC - Lewis lung carcinoma)
Research Area: Cancer research
Conclusions: Emodin is a natural bioactive compound present in various Chinese medicinal herbs. It has multiple functions, including anti-proliferative, anti-tumor, and anti-inflammation. This study investigated the effects of emodin on neutrophil contributions to hypercoagulation and carcinogenesis. Z. Li et al. have suggested novel emodin functions, which led to selectively suppresing N2 type neutrophils and preventing hypercoagulation and lung carcinogenesis. Authors have used HoloMonitor M4 to study neutrophil volume change after emodin exposure.