Authors: Zibo Li, Yukun Lin, Shuhui Zhang, Lin Zhou, Guixi Yan, Yuehua Wang, Mengdi Zhang, Mengqi Wang, Haihong Lin, Qiaozhen Tong, Yongjian Duan, Gangjun Du

Journal: Journal of Translational Medicine (2019)

Institution: Henan University

Research Areas: Cancer research

Cell Lines: HL-60 and LLC (HL-60 – human acute promyelocytic leukemia; LLC – Lewis lung carcinoma)

Summary: Emodin is a natural bioactive compound present in various Chinese medicinal herbs. It has multiple functions, including anti-proliferative, anti-tumor, and anti-inflammation. This study investigated the effects of emodin on neutrophil contributions to hypercoagulation and carcinogenesis. Z. Li et al. have suggested novel emodin functions, which led to selectively suppresing N2 type neutrophils and preventing hypercoagulation and lung carcinogenesis. Authors have used HoloMonitor M4 to study neutrophil volume change after emodin exposure.

Keywords: HoloMonitor M4, Cell morphology, Emodin, Neutrophil phenotypes, NETs, Hypercoagulation, Carcinogenesis