Enhanced Cytotoxicity of Folic Acid-targeted Liposomes Co-loaded With C6 Ceramide and Doxorubicin: in Vitro Evaluation on HeLa, A2780-ADR and H69-AR Cells

S. K. Sriraman et al.

Molecular pharmaceutics (2015)

Institution: Northeastern University, USA

Cell Line: HeLa (Human cervical cancer)

Research Area: Cancer research, Drug development

Tags: HoloMonitor M4, Liposomes, Combination, Drug Therapy, Nanoparticles, Folic Acid, Cancer, Drug Resistance, Receptor Targeting, Apoptosis, Cell Cycle Arrest, Nano medicine, Spheroids

Conclusions: Using holomonitor M4, it was found that FA-(C6+Dox)-LP treated hela cells underwent rapid progression to apoptosis (cell suicide) after 21 hours, as evidenced by a drastic drop in cell area after loss of cell membrane integrity.

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