Customer Publication

Epac1 signaling pathway mediates the damage and apoptosis of inner ear hair cells after noise exposure in a rat model

Authors: Fanfan Sun, Junge Zhang, Li Chen, Yuhao Yuan, Xiaotao Guo, Liuyi Dong, Jiaqiang Sun

Journal: Neuroscience (2021)

Institution: The First Affiliated Hospital of USTC

Research Areas: Neuscience

Cell Lines: HEI-OC1 (Inner ear cell line)

Summary: Noise-induced hearing loss (NIHL) is a major type of sensorineural hearing loss. However, to date, there are no approved drugs for treatment. In this study, F. Sun with colleagues have investigated the role exchange proteins activated (Epac) by cAMP in inner ear hair cell damage and apoptosis after noise exposure. Authors have shown that Epac1 inhibitor protects from NIHL and makes it a potential therapeutic target. HoloMonitor M4 was used to study HEI-OC1 cell proliferation.

Keywords: HoloMonitor M4, cell proliferation, EpacCaMKII, noise-induced hearing loss (NIHL), apoptosis, Hearing loss studies

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