Epac1 signaling pathway mediates the damage and apoptosis of inner ear hair cells after noise exposure in a rat model
Journal: Neuroscience (2021)
Institution: The First Affiliated Hospital of USTC
Research Areas: Hearing loss studies
Cell Lines: HEI-OC1 (Inner ear cell line)
Summary: Noise-induced hearing loss (NIHL) is a major type of sensorineural hearing loss. However, to date, there are no approved drugs for treatment. In this study, F. Sun with colleagues have investigated the role exchange proteins activated (Epac) by cAMP in inner ear hair cell damage and apoptosis after noise exposure. Authors have shown that Epac1 inhibitor protects from NIHL and makes it a potential therapeutic target. HoloMonitor M4 was used to study HEI-OC1 cell proliferation.