Evaluation of the Impact of Imprinted Polymer Particles on Morphology and Motility of Breast Cancer Cells by Using Digital Holographic Cytometry
Applied Sciences (2020)
Institution: Malmö University, Sweden, Czech Republic
Cell Line: MCF-7 and MDAMB231 (MCF-7 breast cancer cell line; MDA-MB-231: Human mammary carcinoma cell line)
Research Area: Cancer treatment
Conclusions: In order to find a way to increase breast cancer patient prognosis, scientists need to understand cell behavior and metastasis. One of the possible tools in the efficient diagnosis is sialic acid-molecularly imprinted polymers (SA-MIPs). The aim of this paper was to study the effects of SA-MIPs on cell morphology and behavior. Using HoloMonitor M4 M. Patel with colleagues show SA-MIP can change cell motility (slower down MCF-7 cells and increase MDAMB231 cell speed), cell morphology for both cell lines.