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Exosomes derived from mesenchymal stem cells repair a Parkinson’s disease model by inducing autophagy

Authors: Hong-Xu Chen, Fu-Chao Liang, Ping Gu, Bian-Ling Xu, Hong-Jun Xu, Wen-Ting Wang, Jia-Yang Hou, Dong-Xiao Xie, Xi-Qing Chai, Sheng-Jun An

Journal: Cell Death and Disease (2020)

Institution: Hebei University of Chinese Medicine

Research Areas: Stem cell research

Cell Lines: hucMSC (Human umbilical cord mesenchymal stem cells)

Summary: Human umbilical cord mesenchymal stem cells (hucMSC) can provide neuroprotection in neurodegenerative diseases, such as Parkinson's disease, treatments. However, at the moment, hucMSC applications are limited due to various reasons. In this study, H.-X. Chen with colleagues has shown that Exosomes derived from hucMSC have the potential for effective Parkinson's disease treatment because they can pass the Brain-Blood barrier. Here, HoloMonitor M4 was used to characterize hucMSC cell proliferation and helped to characterize hucMSC self-renewal and reproductive abilities.

Keywords: HoloMonitor M4, cell proliferation, mesenchymal stem cells, stem cell therapy

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