Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1

X. Zhou et al.

Journal of Medical Chemistry (2019)

Institution: Southern Medical University, China, USA

Cell Line: ACHN (Human renal carcinoma cells)

Research Area: Cytotoxicity

Tags: HoloMonitor M4, Cell proliferation, Lipids,Cancer,Free radicals,Cells,Tumors

Conclusions: X. Zhou with co-workers have evaluated 27 piericidin products against renal cell carcinoma (RCC). Authors have shown that piericidins provide a novel scaffold for further development of anti-RCC agents, and the new action mechanism targeting peroxiredoxin 1 may improve the existing renal cancer drugs. In this study, authors have used HoloMonitor M4 to study ACHN cell proliferation after exposure to 50 nM of piericidin.

Read the article …