Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1
Journal of Medical Chemistry (2019)
Institution: Southern Medical University, China, USA
Cell Line: ACHN (Human renal carcinoma cells)
Research Area: Cytotoxicity
Conclusions: X. Zhou with co-workers have evaluated 27 piericidin products against renal cell carcinoma (RCC). Authors have shown that piericidins provide a novel scaffold for further development of anti-RCC agents, and the new action mechanism targeting peroxiredoxin 1 may improve the existing renal cancer drugs. In this study, authors have used HoloMonitor M4 to study ACHN cell proliferation after exposure to 50 nM of piericidin.