Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1

Authors: X. Zhou et al.

Journal: Journal of Medical Chemistry (2019)

Institution: Southern Medical University

Research Areas: Cytotoxicity

Cell Lines: ACHN (Human renal carcinoma cells)

Summary: X. Zhou with co-workers have evaluated 27 piericidin products against renal cell carcinoma (RCC). Authors have shown that piericidins provide a novel scaffold for further development of anti-RCC agents, and the new action mechanism targeting peroxiredoxin 1 may improve the existing renal cancer drugs. In this study, authors have used HoloMonitor M4 to study ACHN cell proliferation after exposure to 50 nM of piericidin.

Keywords: HoloMonitor M4, Cell proliferation, Lipids,Cancer,Free radicals,Cells,Tumors

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