Customer Publication

Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1

Authors: Xuefeng Zhou, Lan Tang, William Fenical, Shuwen Liu, Yonghong Liu, Shengrong Liao, Zhikun Zhan, Tao Zhang, Xiaowei Luo, Yulian Chen, Wei Fang, Yuanxin Tian,Zhi Liang, Kunlong Li

Journal: Journal of Medical Chemistry (2019)

Institution: Southern Medical University

Research Areas: Cytotoxicity

Cell Lines: ACHN (Human renal carcinoma cells)

Summary: X. Zhou with co-workers have evaluated 27 piericidin products against renal cell carcinoma (RCC). Authors have shown that piericidins provide a novel scaffold for further development of anti-RCC agents, and the new action mechanism targeting peroxiredoxin 1 may improve the existing renal cancer drugs. In this study, authors have used HoloMonitor M4 to study ACHN cell proliferation after exposure to 50 nM of piericidin.

Keywords: HoloMonitor M4, Cell proliferation, Lipids, Cancer, Free radicals, Cells, Tumors

Read the article …