Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1
Journal: Journal of Medical Chemistry (2019)
Institution: Southern Medical University
Research Areas: Cytotoxicity
Cell Lines: ACHN (Human renal carcinoma cells)
Summary: X. Zhou with co-workers have evaluated 27 piericidin products against renal cell carcinoma (RCC). Authors have shown that piericidins provide a novel scaffold for further development of anti-RCC agents, and the new action mechanism targeting peroxiredoxin 1 may improve the existing renal cancer drugs. In this study, authors have used HoloMonitor M4 to study ACHN cell proliferation after exposure to 50 nM of piericidin.