Customer Publication
Exploring the role of PRDX4 in the development of uterine corpus endometrial carcinoma
Journal: Medical Oncology (2024)
Institution: Department of Cell Biology, School of Pharmacy, Binzhou Medical University, Yantai, China
Research Areas: Cancer Research
Cell Lines: KLE and Ishikawa (uterine corpus endometrial carcinoma cells)
Summary: Peroxicedoxin 4 (PRDX4), a member of the peroxicedoxins (PRDXs), has been reported in many cancer-related studies, but its role in uterine corpus endometrial carcinoma (UCEC) is not fully understood. In the present study, they found that PRDX4 was highly expressed in UCEC tissues and cell lines through the combination of bioinformatics analysis and experiments, and elevated PRDX4 levels were associated with poor prognosis. Knockdown of PRDX4 significantly blocked the proliferation and migration of the UCEC cell line Ishikawa and reduced degree of cell confluence. These findings highlight the oncogenic role of PRDX4 in UCEC. In addition, genes that interact with PRDX4 in UCEC were MT-ATP8, PBK, and PDIA6, and suggest that these genes interacted with each other to promote disease progression in UCEC. Thus, PRDX4 is a potential diagnostic biomarker for UCEC, and targeting PRDX4 may be a potential therapeutic strategy for patients with UCEC. HoloMonitor M4 is used to investigate the effect of the knockdown of PRDX4 on the cell fusion and cell migration aspects