Customer Publication

Fibroblasts Cultured on Nanowires Exhibit Low Motility, Impaired Cell Division, and Dna Damage

Authors: Henrik Persson, Carsten Købler, Kristian Mølhave, Lars Samuelson, Jonas O. Tegenfeldt, Stina Oredsson, Christelle N. Prinz

Journal: Small (2013)

Institution: Lund University

Research Areas: Materials of Science

Cell Lines: L929 (Mouse fibroblasts)

Summary: Fibroblast behaviour on vertical nanowire arrays was investigated using the HoloMonitor M3. It was shown that cell motility and proliferation rate are reduced on nanowires. Fibroblasts cultured on long nanowires exhibit failed cell division, DNA damage, increased ROS content and respiration.

Keywords: HoloMonitor M3, cell motility, cell proliferation, cell division, DNA damage, Nanomaterials

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