Authors: Qinguo Fan et al.

Journal: SSRN (2024)

Research Areas: Tissue regeneration

Cell Lines: BMDM cell line (Mouse Bone Marrow-Derived Macrophage (BMDM) cell line)

Summary: The rapid infiltration of macrophages into the wound site after injury is a critical initiator of the inflammatory process, playing a pivotal role in wound healing by modulating inflammation, promoting tissue repair, and facilitating remodeling. The work reported here was to assess the effects of FMS-like tyrosine kinase 3 ligand (FLT3L), which is a cytokine and growth factor, on macrophage proliferation, phenotype, motility, and wound closure capabilities. FLT3L will be used as a topical treatment for advanced wound-healing patches. Using a HoloMonitor, it was shown that the highest concentration of FLT3L enhanced cell proliferation, motility, and gap closure more than other concentrations and the control group.

Keywords: ssrn, flt3l-mediated macrophage modulation for enhanced tissue regeneration, qinguo fan, banafsheh bigdelou, flt3-ligand, macrophages, wound healing, inflammation, flt3l, anti-inflammatory macrophages, m2, wound management