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Generation of Trisomies in Cancer Cells by Multipolar Mitosis and Incomplete Cytokinesis

Authors: David Gisselsson, Yuesheng Jin, David Lindgren, Johan Persson, Lennart Gisselsson, Sandra Hanks, Daniel Sehic, Linda Holmquist Mengelbier, Ingrid Øra, Nazneen Rahman, Fredrik Mertens, Felix Mitelman, Nils Mandahl

Journal: PNAS (2010)

Institution: Lund University

Research Areas: Cancer research

Cell Lines: WiT-49 (Derived from a primary lung metastasis of an aggressive Wilms kidney tumor)

Summary: Gisselsson and colleagues studied cell division in short-term cultures established from fibroblasts and primary tumors. The researchers showed that abnormal cell divisions can cause an abnormal number of chromosomes in cancer cells.

Keywords: HoloMonitor M2, cell division, nondisjunction, aneuploidy, centrosome

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