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Generation of Trisomies in Cancer Cells by Multipolar Mitosis and Incomplete Cytokinesis
Journal: PNAS (2010)
Institution: Lund University
Research Areas: Cancer research
Cell Lines: WiT-49 (Derived from a primary lung metastasis of an aggressive Wilms kidney tumor)
Summary: Gisselsson and colleagues studied cell division in short-term cultures established from fibroblasts and primary tumors. The researchers showed that abnormal cell divisions can cause an abnormal number of chromosomes in cancer cells.