Generation of Trisomies in Cancer Cells by Multipolar Mitosis and Incomplete Cytokinesis

D. Gisselsson et al.

PNAS (2010)

Institution: Lund University, Sweden

Cell Line: WiT-49 (Derived from a primary lung metastasis of an aggressive Wilms kidney tumor)

Research Area: Cancer research

Tags: HoloMonitor M2, cell division, nondisjunction, aneuploidy, centrosome,

Conclusions: Gisselsson and colleagues studied cell division in short-term cultures established from fibroblasts and primary tumors. The researchers showed that abnormal cell divisions can cause an abnormal number of chromosomes in cancer cells.

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