Generation of Trisomies in Cancer Cells by Multipolar Mitosis and Incomplete Cytokinesis
Institution: Lund University, Sweden
Cell Line: WiT-49 (Derived from a primary lung metastasis of an aggressive Wilms kidney tumor)
Research Area: Cancer research
Conclusions: Gisselsson and colleagues studied cell division in short-term cultures established from fibroblasts and primary tumors. The researchers showed that abnormal cell divisions can cause an abnormal number of chromosomes in cancer cells.