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![](https://www.pnas.org/cms/10.1073/pnas.1006829107/asset/573b7399-fbee-481f-ae12-905407bd8643/assets/graphic/pnas.1006829107fig01.jpeg)
Generation of Trisomies in Cancer Cells by Multipolar Mitosis and Incomplete Cytokinesis
Journal: PNAS (2010)
Institution: Lund University
Research Areas: Cancer research
Cell Lines: WiT-49 (Derived from a primary lung metastasis of an aggressive Wilms kidney tumor)
Summary: Gisselsson and colleagues studied cell division in short-term cultures established from fibroblasts and primary tumors. The researchers showed that abnormal cell divisions can cause an abnormal number of chromosomes in cancer cells.