Hypoxia-inducible Factor-1 Alpha Is Involved in Rip-induced Necroptosis Caused by in Vitro and in Vivo Ischemic Brain Injury
Journal: Scientific Reports (2017)
Institution: Tianjin Key Laboratory of Neurotrauma Repair
Research Areas: Ischemic brain injury
Cell Lines: HT-22 (Murine hippocampal neuronal)
Summary: These findings indicate that necroptosis contributes to ischemic brain injury induced by OGD and MCAO and implicate HIF-1α, RIP1, RIP3, and MLKL in necroptosis.