Customer Publication

Imidazole Compounds for Protecting Choroidal Endothelial Cells from Complement Injury

Authors: Shemin Zeng, Kuo-Kuang Wen, Grefachew Workalemahu, Elliott H. Sohn, Meng Wu, Kathleen R. Chirco, Miles J. Flamme-Wiese, Xiuying Liu, Edwin M. Stone, Budd A. Tucker, Robert F. Mullins

Journal: Scientific Reports (2018)

Institution: University of Iowa

Research Areas: Mode of action

Cell Lines: RF/6A (Promate endothelial cells (nonhuman))

Summary: AMD (age-related macular degeneration) is a common and serious eye disease, affecting mostly elderly people. The authors found two drug candidates that seemed to protect endothelial cells from the kind of complement-induced injury and cell death seen in AMD. Using HoloMonitor M4 is was shown that drug pretreatment reduced the cell surface roughness, thus indicating improved cell health.

Keywords: HoloMonitor M4, Cell death, Age-related macular degeneration, Aging

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