Imidazole Compounds for Protecting Choroidal Endothelial Cells from Complement Injury
Journal: Scientific Reports (2018)
Institution: University of Iowa
Research Areas: Aging
Cell Lines: RF/6A (Promate endothelial cells (nonhuman))
Summary: AMD (age-related macular degeneration) is a common and serious eye disease, affecting mostly elderly people. The authors found two drug candidates that seemed to protect endothelial cells from the kind of complement-induced injury and cell death seen in AMD. Using HoloMonitor M4 is was shown that drug pretreatment reduced the cell surface roughness, thus indicating improved cell health.