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Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells

Authors: Agnieszka Bojko, Karolina Staniak, Joanna Czarnecka-Herok, Piotr Sunderland, Magdalena Dudkowska, Małgorzata Alicja Śliwińska, Kristine Salmina, Ewa Sikora

Journal: International Journal of Molecular Sciences (2020)

Institution: Polish Academy of Sciences

Research Areas: Cancer research

Cell Lines: MDA-MD-231 (MDA-MB-231 – Human mammary carcinoma cell line)

Summary: It is hypothesized that cell senescence can induce cancer recurrence and together with cell autophagy reduces chances of cancer patient recovery. In this study, A. Bojko with colleagues aimed to understand autophagy modulation in breast cancer cell-induced senescence after doxorubicin treatment. Authors have shown that breast cancer cells can undergo senescence uncoupled from autophagy status. HoloMonitor M4 was used to study asymmetric cell proliferation.

Keywords: HoloMonitor M4, Cell proliferation, autophagy, autophagic index, cancer, DNA damage, SQSTM1/p62, polyploidy, senescence, senescence escape, TFEB, Rubicon

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