In vitro SOD-like activity of mono- and di-copper complexes with a phosphonate substituted SALAN-type ligand

Authors: I. Székácsa et al.

Journal: Chemico - Biological Interactions (2019)

Institution: Hungarian Academy of Sciences

Research Areas: Cytotoxicity

Cell Lines: MC3T3-E1 (Osteoblast-like cells)

Summary: Malfuntioning superoxide dismutase (SOD) enzymes are linked to the imbalanced levels of radicals and various pathological conditions, including cancer. Thus, Szekacs with co-workers have studied two SOD mimiking agents functions, reactivity and toxicity. Authors have found that one analog, Cu[L], can be a promising copper based platform for biochemical and phamaceutical applications. HoloMonitor M4 was used to study SOD analog effects MC3T3-E1 cell morphology and proliferation changes for 72 hours after exposure. Authors have shown that Cu[L] can be tolerated by cells in vitro at high concentrations, while Cu2[L] induced cell changes, inplying cytotoxic effects.

Keywords: HoloMonitor M4, Cell morphology, Cu-complex, SALAN, Antioxidant, SOD-Like activity, In vitro cytotoxicity

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