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In vitro SOD-like activity of mono- and di-copper complexes with a phosphonate substituted SALAN-type ligand

Authors: Inna Székács, Paweł Tokarz, Robert Horvath, Krisztina Kovács, Adam Kubas, Mari Shimura, Justyna Brasun, Vadim Murzin, Wolfgang Caliebe, Zbigniew Szewczuk, Aneta Paluch, László Wojnárovits, Tünde Tóth, József S. Pap, Łukasz Szyrwiel

Journal: Chemico – Biological Interactions (2019)

Institution: Hungarian Academy of Sciences

Research Areas: Cytotoxicity

Cell Lines: MC3T3-E1 (Osteoblast-like cells)

Summary: Malfuntioning superoxide dismutase (SOD) enzymes are linked to the imbalanced levels of radicals and various pathological conditions, including cancer. Thus, Szekacs with co-workers have studied two SOD mimiking agents functions, reactivity and toxicity. Authors have found that one analog, Cu[L], can be a promising copper based platform for biochemical and phamaceutical applications. HoloMonitor M4 was used to study SOD analog effects MC3T3-E1 cell morphology and proliferation changes for 72 hours after exposure. Authors have shown that Cu[L] can be tolerated by cells in vitro at high concentrations, while Cu2[L] induced cell changes, inplying cytotoxic effects.

Keywords: HoloMonitor M4, Cell morphology, Cu-complex, SALAN, Antioxidant, SOD-Like activity, In vitro cytotoxicity

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