Customer Publication

In vitro SOD-like activity of mono- and di-copper complexes with a phosphonate substituted SALAN-type ligand

Authors: I. Székácsa et al.

Journal: Chemico - Biological Interactions (2019)

Institution: Hungarian Academy of Sciences

Research Areas: Cytotoxicity

Cell Lines: MC3T3-E1 (Osteoblast-like cells)

Summary: Malfuntioning superoxide dismutase (SOD) enzymes are linked to the imbalanced levels of radicals and various pathological conditions, including cancer. Thus, Szekacs with co-workers have studied two SOD mimiking agents functions, reactivity and toxicity. Authors have found that one analog, Cu[L], can be a promising copper based platform for biochemical and phamaceutical applications. HoloMonitor M4 was used to study SOD analog effects MC3T3-E1 cell morphology and proliferation changes for 72 hours after exposure. Authors have shown that Cu[L] can be tolerated by cells in vitro at high concentrations, while Cu2[L] induced cell changes, inplying cytotoxic effects.

Keywords: HoloMonitor M4, Cell morphology, Cu-complex, SALAN, Antioxidant, SOD-Like activity, In vitro cytotoxicity

Read the article …

Phase Holographic Imaging PHI AB
Skiffervägen 48
224 78 Lund
Sweden
+46 46 38 60 80
info@phiab.se

Phase Holographic Imaging PHI Inc.
265 Franklin Street Suite 1702
Boston, MA 02110
USA
+1 617-963-5150
info@phiab.com

Invoicing

VAT: SE556542781101
faktura@phiab.se

Securities Identification

ISIN: SE0005504636
LEI: 549300JZR79QYESM6296

HoloMonitor® is a registered trademark
Copyright © 2012-2021
Phase Holographic Imaging PHI AB

Phase Holographic Image logo in white

PHI Theme 3.12.2