Customer Publication

Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells

Authors: Hiroyuki Ogawa, Michiyo Koyanagi-Aoi, Kyoko Otani, Yoh Zen, Yoshimasa Maniwa, Takashi Aoi

Journal: Scientific Reports (2017)

Institution: Kobe University

Research Areas: Cancer research

Cell Lines: A549 (Human lung cancer cells)

Summary: The authors established technologies to generate lung CSC (cancer stem cell) -like cells from human lung cancer cell line A549 by introducing OCT3/4, SOX2 and KLF4, and to construct “lung cancer organoids” in vitro that mimicked human lung cancer tissues. Through the use of these technologies and the evaluation of clinical samples, interleukin-6 was identified as a novel potential therapeutic target for lung cancer stem cells.

Keywords: HoloMonitor M4, Cell motility, Cancer stem cell

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