Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells

H. Ogawa et al.

Scientific Reports (2017)

Institution: Kobe University, Japan

Cell Line: A549 (Human lung cancer cells)

Research Area: Cancer research

Tags: HoloMonitor M4, Cell motility, Cancer stem cell

Conclusions: The authors established technologies to generate lung CSC (cancer stem cell) -like cells from human lung cancer cell line A549 by introducing OCT3/4, SOX2 and KLF4, and to construct “lung cancer organoids” in vitro that mimicked human lung cancer tissues. Through the use of these technologies and the evaluation of clinical samples, interleukin-6 was identified as a novel potential therapeutic target for lung cancer stem cells.

Read the article …