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Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity from Streptomyces sp. KCB15JA15

Authors: Jun-Pil Jang, Gil Soo Kim, Tae Hoon Oh, Beomcheol Pard, Minhee Kim, Gwi Ja Hwang, Hyeok-Won Lee, Jin-Gyeom Lee, Young-Soo Hong, Jong Seog Ahn, Sung-Kyun Ko, Jae-Hyuk Jang

Journal: RSC Advances (2022)

Institution: Korea Research Institute of Bioscience and Biotechnology

Research Areas: Cancer research

Cell Lines: PC12, HeLa, A549, MEF, MDA-MB-231 (pheochromocytoma of rat adrenal medulla, Human cervix cancer, Human lung cancer, Mouse Embryonic Fibroblasts, Human breast cancer)

Summary: Two new polyketide glycosides jejuketomycins A (1) and B (2), were isolated from a culture of Streptomyces sp. KCB15JA151. Their chemical structures including the absolute configurations, were determined by detailed analyses of the NMR and HRMS data and ECD calculations and spectral data. Compounds 1 and 2 possess an unusual 6/6/8 tricyclic ring system. Biological evaluation with the wound healing assay and time-lapse cell tracking analysis revealed that compounds 1 and 2 have significant inhibitory activities against cancer cell migration with low cytotoxicity.HoloMonitor M4 was used for single cell tracking study.

Keywords: HoloMonitor, single cell tracking

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