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Living Biointerfaces for the Maintenance of Mesenchymal Stem Cell Phenotypes
Journal: Advanced functional materials (2022)
Research Areas: Stem cell research
Cell Lines: hMSC (Primary human bone-marrow derived mesenchymal stem cells)
Summary: In this paper, the authors demonstrate the potential of genetically engineered living biointerfaces to actively control stem cell behavior. The results showed hMSCs could be successfully cultured on L. lactis biofilms, retaining high viability and displaying adhesion dynamics and cell movement comparable to traditional culture methods. Furthermore, this active microenvironment can maintain key hMSC stemness markers, preventing their osteogenic and adipogenic differentiation and maintaining high stem cell viability and physiological cell-to-substrate adhesion dynamics.