Loss of Erα Induces Amoeboid-like Migration of Breast Cancer Cells by Downregulating Vinculin
Nature Communications (2017)
Institution: The Fourth Military Medical University, China
Cell Line: MCF-7 (Human breast cancer cultured in matrigel)
Research Area: Cancer research
Conclusions: The authors tracked and analyzed the migration of different MCF-7 cell populations in a 3D matrix. In addition to measuring the cell migration speed with HoloMonitor, the following five phenotypes were observed: ‘stable adhesion’, ‘unstable lamellipodia’, ‘bleb’, ‘stable bleb’ and ‘unstable pseudopod’.