Loss of Erα Induces Amoeboid-like Migration of Breast Cancer Cells by Downregulating Vinculin

Y. Gao et al.

Nature Communications (2017)

Institution: The Fourth Military Medical University, China

Cell Line: MCF-7 (Human breast cancer cultured in matrigel)

Research Area: Cancer research

Tags: HoloMonitor M4, Cell motility

Conclusions: The authors tracked and analyzed the migration of different MCF-7 cell populations in a 3D matrix. In addition to measuring the cell migration speed with HoloMonitor, the following five phenotypes were observed: ‘stable adhesion’, ‘unstable lamellipodia’, ‘bleb’, ‘stable bleb’ and ‘unstable pseudopod’.

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