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Loss of Erα Induces Amoeboid-like Migration of Breast Cancer Cells by Downregulating Vinculin
Journal: Nature Communications (2017)
Institution: The Fourth Military Medical University
Research Areas: Cancer research
Cell Lines: MCF-7 (Human breast cancer cultured in matrigel)
Summary: The authors tracked and analyzed the migration of different MCF-7 cell populations in a 3D matrix. In addition to measuring the cell migration speed with HoloMonitor, the following five phenotypes were observed: ‘stable adhesion’, ‘unstable lamellipodia’, ‘bleb’, ‘stable bleb’ and ‘unstable pseudopod’.