Customer Publication

Mannich Curcuminoids as Potent Anticancer Agents

Authors: Márió Gyuris, László Hackler Jr., Lajos I. Nagy, Róbert Alföldi, Eszter Rédei, Annamária Marton, Tibor Vellai, Nóra Faragó, Béla Ózsvári, Anasztázia Hetényi, Gábor K. Tóth, Péter Sipos, Iván Kanizsai, László G. Puskás

Journal: Archiv der Pharmazie (2017)

Institution: AVIDIN Ltd., Szeged

Research Areas: Drug research

Cell Lines: A549 and H1975 (Lung adenocarcinoma cells)

Summary: Structure–activity relationship (SAR) studies were performed by applying viability assays and holographic microscopic imaging to these curcumin analogues for anti-proliferative activity against A549 and H1975 lung adenocarcinoma cells. The TNFα-induced NF-κB inhibition and autophagy induction effects correlated strongly with the cytotoxic potential of the analogues. Significant inhibition of tumour growth was observed when the most potent analogue 44 was added in liposomes at one-sixth of the maximally tolerated dose in the A549 xenograft model.

Keywords: HoloMonitor M3, Cell morphology, Drug development

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