Mannich Curcuminoids as Potent Anticancer Agents

M. Gyuris et al.

Archiv der Pharmazie (2017)

Country: Hungary

Cell Line: A549 and H1975 (Lung adenocarcinoma cells)

Research Area: Drug development

Tags: HoloMonitor M3, Cell morphology

Conclusions: Structure–activity relationship (SAR) studies were performed by applying viability assays and holographic microscopic imaging to these curcumin analogues for anti-proliferative activity against A549 and H1975 lung adenocarcinoma cells. The TNFα-induced NF-κB inhibition and autophagy induction effects correlated strongly with the cytotoxic potential of the analogues. Significant inhibition of tumour growth was observed when the most potent analogue 44 was added in liposomes at one-sixth of the maximally tolerated dose in the A549 xenograft model.

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