Authors: Shuya Yang, Xiyang Zhang, Yuanjie Sun, Jingqi Shi, Dongbo Jiang, Jing Wang, Yang Liu, Chenchen Hu, Jingyu Pan, Lianhe Zheng, Kun Yang

Journal: Frontiers in Molecular Biosciences (2020)

Institution: The Fourth Military Medical University

Research Areas: Cancer research

Cell Lines: HeLa (Cervical cancer cell line)

Summary: MicroRNAs play one of the key roles in cervical cancer metastasis. Thus, in this study, S. Yang with colleagues have investigated the miR-362-3p targeting mechanism and effect. Authors have shown that miR-263-3p plays an important role in cervical cancer metastasis, as it regulates cell migration and motility by directly targeting BCAP31 protein. Hence, making miR-263-3p a potential target for cervical cancer treatment. Here, HoloMonitor M4 was used to characterize HeLa cell migration and motility after transfection.

Keywords: HoloMonitor M4, Cells movements, miR-362-3p, BCAP31, cervical cancer, migration, invasion